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br Conclusions br Declarations br Introduction The
2024-05-31
Conclusions Declarations Introduction The classical term of endocrine disruption includes any agent that interferes with the action of hormones within the human body; these agents are therefore named endocrine disruptors. Among these agents, that are mainly environmental chemicals (pollutan
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The major phase trial NCT enrolled participants with mild to
2024-05-31
The major phase 2 trial (NCT01343966) enrolled 431 participants with mild to moderate AD who received either low-dose SC crenezumab 300 mg or placebo biweekly (n = 184) or high-dose intravenous crenezumab 15 mg/kg or placebo every 4 weeks (n = 247) for 68 weeks 38, 40. No significant treatment benef
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The importance of TARPs for AMPAR expression
2024-05-31
The importance of TARPs for AMPAR expression and function was revealed initially in the cerebellum, where the lack of γ-2 in the mutant mice waggler and stargazer (stg/stg) was associated with a selective loss of AMPAR-mediated synaptic currents in cerebellar granule leukotriene receptor antagonists
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Following activation of mGluRs GRIP stabilized AMPARs appear
2024-05-31
Following activation of mGluRs, GRIP-stabilized AMPARs appear to be the primary target for endocytosis. Consistent with this model, we find that using siRNA to reduce GRIP1/2 expression blocks the AMPAR internalization and the synaptic depression mediated by mGluRs. Reductions in GRIP1/2 expression,
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The excellent potencies selectivities and improved PK associ
2024-05-31
The excellent potencies, selectivities and improved PK associated with the piperazine class triggered more extensive off-target screenings of the highlighted compounds. A screen of more than 100 enzymes, receptors, and ion channels resulted in activity at the norepinephrine transporter (NET). This m
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The Cebu Longitudinal Health and Nutrition Survey CLHNS
2024-05-31
The Cebu Longitudinal Health and Nutrition Survey (CLHNS) genome-wide association study investigated the genetic loci associated with plasma adiponectin in 1776 unrelated Filipino women. Adiponectin was strongly associated with three genetic positions: the gene CDH13 (rs3865188, P ≤ 7.2 × 10−16), ne
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Although the effects of adenosine receptor
2024-05-31
Although the effects of adenosine receptor signaling in acute renal IRI have been attributed to the generation of high concentrations of adenosine, we have recently reported an increase in kidney levels of both AMP and adenosine, with a concomitant fall in ATP and ADP. We have also previously demons
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Streptomycetes are a group of
2024-05-31
Streptomycetes are a group of filamentous Gram-positive, soil-inhabiting bacteria which have captured enormous screening interest because of their ability to produce and secrete a variety of PFI-2 and extracellular proteins [7]. Among the diverse antibiotics produced by Streptomycetes are the nucleo
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br Acknowledgment br Introduction Vascular smooth muscle cel
2024-05-31
Acknowledgment Introduction Vascular smooth muscle cells (VSMC) exhibit the capacity to switch between a differentiated (contractile) and a dedifferentiated (synthetic) phenotype [1]. Synthetic VSMC express a lower amount of contractile proteins such as Smooth muscle 22α (sm22α) and α-Smooth m
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br Materials and methods All animal
2024-05-31
Materials and methods All animal experiments were performed using the recommendations of the Guide for the Care and Use of Laboratory Animals (National Research Council, 2011) and approved by the University of Colorado—Denver Institutional Animal Care and Use Committee. Adult male Sprague—Dawley
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This study does have several limitations mainly related
2024-05-31
This study does have several limitations, mainly related to the DMSO vehicle. While DMSO is a known anti-inflammatory mediator,5, 12 it has been shown to upregulate ALOX5, which was not seen in this study (as we are likely underpowered to detect this difference). A manifestation of this anti-inflamm
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HT receptors are distributed throughout the brain within the
2024-05-31
5-HT3 receptors are distributed throughout the brain, within the brainstem (e.g., nucleus tractus solitarius, area postrema and spinal trigeminal nucleus) and Cobicistat synthesis (e.g., hippocampus, amygdala, nucleus accumbens, putamen and caudate) (Abi-Dargham et al., 1993, Barnes et al., 1989, B
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In conclusion we have produced some highly potent inhibitors
2024-05-31
In conclusion, we have produced some highly potent inhibitors of P450 in comparison to the standard octanoic acid KTZ. Also, due to the limited specificity of these compounds against lyase in comparison to the 17α-OHase component, these compounds would be expected to have a major impact on corticos
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Mevastatin The H N mutation in exon has
2024-05-31
The H373N mutation in exon 6 has not previously been reported [3], [4], [5], [6]; thus, this mutation appears to be a novel mutation. The functional expression study demonstrated that the H373N mutation results in almost complete loss of enzymatic activity. Thus, it is highly likely that the H373N m
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br Conclusion br Acknowledgments This research has been supp
2024-05-31
Conclusion Acknowledgments This research has been supported by the Ratchadaphiseksomphot Endowment Fund 2013 of Chulalongkorn University (CU-56-341-AS) and the Ratchadapiseksompotch Fund (RA55/22), Faculty of Medicine, Chulalongkorn University. The authors commemorate the 100th Anniversary of
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