• In countries such as China where there is a

  2021-05-27

  

  In countries such as China where there is a high commercial production of rice, the use of rice husk ash (RHA) as an alternative cementing material can become a great asset for environmental rehabilitation and address the difficult disposal issues associated with this agricultural waste [23]. RHA po

• Several recent reviews have appeared covering different aspe

  2021-05-27

  

  Several recent reviews have appeared covering different aspects of the sPLA2 family of enzymes, including sPLA2-V, and the interested reader is kindly directed to these for specific details [34,[135], [136], [137]]. It is important to remark here, however, that recent studies on sPLA2-V suggest that

• A structural explanation for how RBR RING

  2021-05-27

  

  A structural explanation for how RBR RING1s handle their bound E2~Ubs differently from canonical RINGs has not been readily apparent. Only a few residue positions are strongly conserved in RING and RING1 domains, most of which are zinc-coordinating Cys and histidine residues. A key position in canon

• Acknowledgments br Introduction Diabetes mellitus DM

  2021-05-27

  

  Acknowledgments Introduction Diabetes mellitus (DM) is a multifactorial disease [1] associated with serious comorbidities. This condition has recently reached epidemic proportions, as its occurrence has exponentially increased in the general population. Over 400 million people worldwide were est

• Acknowledgments We are grateful to Dr Jean Marie Bernassau f

  2021-05-27

  

  Acknowledgments We are grateful to Dr. Jean-Marie Bernassau for his leadership in establishing our virtual screening platform and Dr. Julie Bick for protein purification. X-ray data collection for compound 4 was performed by Shamrock Structures at Southeast Regional Collaborative Access Team (SER-C

• Given the excellent in vitro pharmacology profiles of

  2021-05-27

  

  Given the excellent in vitro pharmacology profiles of methyl ester 28 and primary amide 29 efforts were reengaged on neutral analogs of these leads, with a focus on non-amide replacements for the carboxylic phenanthroline functionality of 1. Acetonitrile 49 was found to have a good balance of DGAT-

• Functional studies suggested the presence of a cysLT recepto

  2021-05-26

  

  Functional studies suggested the presence of a cysLT1 receptor. We observed an LTD4-induced cytosolic calcium response, albeit one that was very weak by most standards. The magnitude of the average response was partially explained by the low percentage of ARCA showing a very transient response. Beca

• As described above we designed and synthesized

  2021-05-26

  

  As described above, we designed and synthesized a new 1,4-di-substituted isoquinoline lead compound, and was identified as a ligand with moderate potency for the CRTH2 receptor. We initially we examined the effects of the steric factor of R group on the CRTH2 binding potency (). When the methyl gro

• We also identified a role for the

  2021-05-26

  

  We also identified a role for the transcription factor p53 in the regulation of the Crm1 promoter. p53 can activate or repress the transcription of target genes. While activation generally occurs through binding of p53 to its consensus binding site in the promoter region of target genes, for example

• br Material and methods br

  2021-05-26

  

  Material and methods Results Discussion The present study shows that peripheral administration of the nonpeptidic corticotropin-releasing factor CRF1 receptor antagonist CP-154,526 before a social defeat inhibits the development of CPP induced with a subthreshold dose of cocaine and reverse

• With this we find This is all that

  2021-05-26

  

  With this we find This is all that one can say for , however when there is also a negative TASIN-1 solution which is a bound state. One must have in this case, up to a normalization constantwith K>0. The delta potential now imposes or and one has as the energy of the bound state. The enzyme ana

• br Introduction As a serine proteinase and

  2021-05-26

  

  Introduction As a serine proteinase and a sub-family of the chymotrypsin-like proteinase, Glutamyl endopeptidase (GE), which is mainly found in Bacillus species, specifically cleaves negatively charged amino TCS 2002 receptor residues (Glu/Asp) (Yokoi et al., 2001). Madsen et al. (Madsen & Qvist,

• br Results br Discussion The process by which MBCs

  2021-05-26

  

  Results Discussion The process by which MBCs differentiate from GC B cell precursors remains mostly uncharacterized, in large part because of the uncertainty surrounding the nature of the precursor PRT 4165 mg within the GC. The identification here of a distinct subset of GC B cells, CCR6+ LZ

• br Significance Our understanding of the ubiquitin biology

  2021-05-25

  

  Significance Our understanding of the ubiquitin biology has been rapidly expanding. The role of the ubiquitin system in the pathogenesis of numerous disease states has increased the interest in finding new strategies to pharmacologically interfere with the enzymes responsible of the ubiquitinatio

• The roles of ginsenoside in

  2021-05-25

  

  The roles of ginsenoside in E1 and 26S proteasome inhibition are shown in Table 2. The nitro substitute on the furan ring may be important for PYR-41 inhibition of the E1 enzyme (Yang et al., 2007). The macrocycle core and aliphatic tail of Largazole are responsible for inhibiting E1 activity (Unger

14283 records 634/953 page Previous Next First page 上5页 631632633634635 下5页 Last page