• The AURA trial was a phase I II study evaluating

  2021-01-18

  

  The AURA trial was a phase I/II study evaluating the safety, tolerability and activity of Osimertinib in patients with EGFR-mutated NSCLC progressing after a previous EGFR TKI. The phase I component of the study included a dose escalation part (Osimertinib 20mg to 240mg), using a rolling six design,

• br Guidance of B cell localization by

  2021-01-18

  

  Guidance of B cell localization by EBI2 EBI2 expression and B cell disease Although chemoattractant receptors of the GPR family play essential roles in coordinating the migration of lymphocytes for efficient responses against pathogens, their dysregulation can result in the initiation or progr

• BR stimulated PA formation via the DGK pathway might

  2021-01-18

  

  BR-stimulated PA formation via the DGK pathway might have many effects in regulation of cell metabolism. For example, PA originated from DGKs pathway plays important roles in activation of NADPH oxidases, thus turning on ROS signaling [23]. PA is also connected to regulation of respiration processes

• AQP protein expression was determined by Western blot

  2021-01-18

  

  AQP4 protein expression was determined by Western blot analysis. Briefly, protein samples (50μg) from brains or astrocytes were separated by 12% SDS–polyacrylamide gel electrophoresis and transferred to nitrocellulose membranes. The membranes were reacted with a rabbit polyclonal antibody against AQ

• br Conclusion Blueberry is becoming

  2021-01-18

  

  Conclusion Blueberry is becoming a worldwide crop with the fastest rising consumer demand trends for its health benefits. However, the berry size is one of the key parameters for determining fruit quality and consumers’ preferences (Milic et al., 2018). Understanding the physiological and molecul

• Nicotine is the main psychoactive component of tobacco that

  2021-01-18

  

  Nicotine is the main psychoactive component of tobacco that causes addiction. Besides the regulation of the stress responses, CRF has been implicated in nicotine addiction based on several lines of evidence (Bruijnzeel and Gold, 2005, Sarnyai et al., 2001). First, acute administration of nicotine, l

• Recent studies showed that the activity of CK was

  2021-01-18

  

  Recent studies showed that the activity of CK2 was significantly reduced in ischemic stroke model rats, and cerebral I/R injury significantly decreased the expression of CK2α (Lee et al., 2004; Kim et al., 2012; Zhou et al., 2016). In addition, the dysregulation of CK2 is involved in ERS/UPR in non-

• Another important consideration with respect to drug conditi

  2021-01-15

  

  Another important consideration with respect to drug conditioning suggested by the present findings is the observation of an attenuated Alfacalcidol on the second extinction trial. Seemingly, if ERK measurements were made following a partial reduction in the conditioned response the ERK response wo

• The hepatic constitutive levels of CYP A were

  2021-01-15

  

  The hepatic constitutive levels of CYP1A2 were minimal and were below detectable limits in the kidney, indicating an organ-specific trend which has been reported by other groups (Hawke and Welch, 1985, Paolini et al., 1997, Parkinson, 1996, Villard et al., 1998). Retinol administration did not have

• Given its high frequency it is not surprising

  2021-01-15

  

  Given its high frequency, it is not surprising that different strategies have been developed to restore the sensitivity of EGFR T790M-mutant beta lactamase to EGFR inhibition. To date, several different strategies have been evaluated in both preclinical and clinical models, but only few have been pr

• GSK2606414 Consistent with a clear separation of biological

  2021-01-15

  

  Consistent with a clear separation of biological function between ARISC and BRISC in cells, mutations in BRCC36 and Abraxas are prevalent in cancer genomes whereas mutations in KIAA0157 are rare. A survey of the Catalogue of Somatic Mutations in Cancer (COSMIC) consortium, revealed that to date, 37

• DGAT is specifically responsible for endogenous synthesis of

  2021-01-15

  

  DGAT2 is specifically responsible for endogenous synthesis of TAGs which are then packed into cytosolic LDs in the cytosol for storage and luminal apolipoprotein B (apoB)-containing LDs in the ER lumen destined for VLDL secretion [122,127]. DGAT2 can also synthesize TAG using exogenous FAs and suppo

• A previous report showed that

  2021-01-15

  

  A previous report showed that the transfer of the CSF1 gene into tumor Ferulenol australia induced TAM infiltration into syngeneic BALB/c mice. High expressions of CSF-1 and CSF-1R in tumor and stromal cells and a high TAM density are known to be correlated with poor prognoses in many cancer types.

• Increasing age among middle aged subjects years

  2021-01-15

  

  Increasing age among middle-aged subjects (30–59years old) was associated with higher levels of cholesterol synthesis markers (although without statistical significance) and also of cholesterol clofibrate markers (with statistical significance for campesterol and sitosterol); this finding is consis

• (+)-Bicuculline Initially studies of GPCRs predominantly ass

  2021-01-15

  

  Initially, studies of GPCRs predominantly assessed the signalling pathways downstream of receptors on the cell surface. There is now an understanding that GPCRs can localize to and signal from various intracellular compartments, such as the nucleus (reviewed in [40]). These intracellular pools of re

13934 records 684/929 page Previous Next First page 上5页 681682683684685 下5页 Last page