• c-Myc tag br Conflict of interest br Acknowledgements

  2020-07-09

  

  Conflict of interest Acknowledgements This work was funded by the National Science Centre, Poland, grant number N N303 571539. We are greatly indebted to Patrick Fox for help with the final manuscript. Introduction Alkylating agents which interact directly with DNA to form covalent bonds h

• In this study we have developed and investigated three NADPH

  2020-07-08

  

  In this study we have developed and investigated three NADPH-regenerating fusion partners with two different enzyme systems: a BVMO and an ADH. With the exception of one fusion construct (StGDH with LbADH), all fusion Sodium salicylate sale resulted in good soluble expression as well as fully funct

• The notion that a small subset of inducible cellular

  2020-07-08

  

  The notion that a small subset of inducible cellular transcripts, encoding immunological important factors, is translocated across the nuclear envelope by the karyopherin CRM1 is gaining support from various recent studies. For example, experimental evidence has been provided demonstrating that the

• Prostaglandins production and some of their possible biologi

  2020-07-08

  

  Prostaglandins production and some of their possible biological functions have been reported in protozoa, helminths, and fungi organisms, for example amphizoic amoebas of the genus Acanthamoeba and Entamoeba (E. histolytica) produce PGA2, PGE2 and PGF2α [5,6]. PGA2 is believed to be an intrinsic osm

• In frame exon skipping of COL A

  2020-07-08

  

  In frame exon 41 skipping of COL6A3 has been suspected to be responsible for isolated dystonia in several human kindreds without muscular defects [94]. In order to validate their hypothesis, the authors used zebrafish to selectively knock down several exons in col6a3 and found a negative impact on m

• br Results and Discussion br Conclusion What

  2020-07-08

  

  Results and Discussion Conclusion What we have shown here is that highly specific antagonist can be a very useful tool, can mimic gene KO experiments or even further dissect receptor function. We just took ETA antagonist as an example and found that ETA mediates physiological closure of DA whi

• It has previously been shown

  2020-07-08

  

  It has previously been shown that human melanocytes are responsive to a multiplicity of hormonal triggers [10], particularly to pituitary or ovarian hormones [11]. Studies concerning the effects of Purvalanol B on human melanocytes led to inconsistent data [12], [13]. Im et al. [14] reported that t

• Identification of the drug to be used as first

  2020-07-08

  

  Identification of the drug to be used as first-step antihypertensive treatment has always been, and remains, a matter of debate. The decision wihich drug (or drug combination) to choose as first-line therapy depend on many variables such as coexisting metabolic disorders, obesity, presence of subcli

• Just as Dorin et al and Nguyen

  2020-07-08

  

  Just as Dorin et al. [2] and Nguyen et al. [3] write in regard to their models, our static model can be used to estimate the affinities of KN-62 to albumin and CBG. Dorin et al. [2] estimates the K, but not K, since they find that their model is not particular sensitive towards changes in K. Our se

• In the present study we identified that SDF could

  2020-07-07

  

  In the present study, we identified that SDF-1α could significantly elevate the expression of p-P65 in the NF-κB signaling pathway and p-Akt in the PI3K-Akt signaling pathway, while significantly reducing the expression of p-IκB in the NF-κB signaling pathway. AMD3100 and hesperidin antagonized the

• ERR is constitutively active in the absence of

  2020-07-07

  

  ERRγ is constitutively active in the absence of endogenous ligand. However, several synthetic ligands that can repress or induce ERRγ function by disrupting ERRγ-coactivator interactions have been reported to date. The estrogen receptor modulators diethylstilbestrol (DES) and 4-hydroxytamoxifen (4-O

• It is very important to

  2020-07-07

  

  It is very important to decide what the best time of NIR laser irradiation is for the optimized PTT. So the best way is to monitor the biodistribution of the nanoparticles in various tissues (specially, in tumors) temporally and spatially after iv injection. Based on the combined functions of therap

• br Oxidoreductase like MEM for prodrug

  2020-07-07

  

  Oxidoreductase-like MEM for prodrug activation Future outlook Although MEM-mediated prodrug activation has been performed by different MEMs and prodrugs, and their effectiveness have been proved in vivo, only a few types of MEMs or prodrugs have been explored in prodrug activation until now [2

• br Material and methods br Results

  2020-07-07

  

  Material and methods Results and discussion Conclusion The gene encoding the Bos taurus muscle enolase enzyme was successfully isolated and cloned in this study. Optimization of the cloning, gene Fusidic Acid sodium salt and purification was performed and protein elution at 95% purity was

• Although enantioselective accumulation of metalaxyl in organ

  2020-07-07

  

  Although enantioselective accumulation of metalaxyl in organisms is an integrated outcome of bio-process including absorption, transportation, and transformation, it is observed in our study that catalysis of CYP450 may lead to the enantioselective accumulation of metalaxyl. However, the mechanisms

13909 records 776/928 page Previous Next First page 上5页 776777778779780 下5页 Last page